Zantac Lawsuit Update 2021 (Updated For September) - Zayed ... in Rochester, New York

Published Oct 14, 21
5 min read

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Zantac Recalled Due To Cancer Causing Ndma - Messa ... in Anchorage, AlaskaZantac (Ranitidine) Lawyer And Lawsuits - Edgar Snyder ... in Anchorage, Alaska


Other symptoms of NDMA exposure include headaches, fever, nausea, jaundice, vomiting, abdominal cramps, enlarged living, dizziness, and reduced function of the liver, kidneys, and lungs. Plaintiffs accuse drugmakers Sanofi and Boehringer Ingelheim of manufacturing and marketing a medication they knew, or should have known, to be contaminated with the cancer-causing chemical without disclosing the risks to consumers or the government.

The makers of Zantac, a popular heartburn medication, are facing a Zantac cancer lawsuit claiming the drug contains unsafe levels of the cancer-causing substance N-Nitrosodimethylamine (NDMA) which caused plaintiffs to develop cancer. Plaintiffs accuse drugmakers Sanofi and Boehringer Ingelheim of manufacturing and marketing a medication they knew, or should have known, to be contaminated with the cancer-causing chemical without disclosing the risks to consumers or the government.

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Mass Torts » Zantac Lawsuit » Zantac Lawsuit.

Zantac Replacement – What are the FDA Recommended Zantac Alternatives? Deciding on a safe alternative to Zantac is something you should discuss with your doctor. The U.S. Food and Drug Administration’s (FDA) recommends the following Zantac replacement options: Prilosec (omeprazole) – A proton pump inhibitor (PPI) medication commonly used to treat stomach acid-related conditions, including gastroesophageal reflux disease (GERD).

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Prevacid (lansoprazole) – A proton pump inhibitor (PPI) recommended for short-term ulcer and acid reflux treatment. Pepcid (famotidine) – An H2 blocker that treats ulcers, GERD, and conditions that cause excess stomach acid. Tagamet (cimetidine) – An H2 blocker that reduces acid in the stomach to treat ulcers and acid reflux.

Below we highlight some of the most important research on Zantac. 2019 Valisure Study: How Zantac (Ranitidine) Produces NDMA In 2019, Valisure conducted batch testing for Zantac (ranitidine) using FDA-recommended protocols. Valisure found NDMA levels as high as 3,267,968 ng (nanograms) per Zantac tablet, more than 34,000 times higher than the FDA limit of 96 ng or .

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Wondering if the increased heat of the testing process may have contributed to these results, Valisure decided to test ranitidine under conditions that simulated those found in the stomach (simulated gastric fluid with sodium nitrite). NDMA levels, while not as high, were still extraordinary, ranging from 23,600 ng to 304,500 ng, over 3,100 times the FDA’s “safe” limit.

2021 Valisure Study on Zantac (Ranitidine) The 2021 Valisure Zantac study analyzed NDMA production “under simulated physiologic gastric states.” What does this mean exactly? Researchers conducted the study by mimicking the human stomach ingesting a Zantac tablet across a broad range of p, H concentrations, ranitidine concentrations, and nitrite concentrations.

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The study found that Zantac “may be a significant source of NDMA under a range of physiologically relevant conditions.” Under numerous conditions meant to simulate the human stomach, Zantac NDMA levels increased with increasing nitrite levels and decreasing p, H levels up to three orders of magnitude beyond established limits.

Researchers looked at data from the FDA’s Adverse Events Reporting System (FAERS), searching adverse event reports of cancer stemming from primary and secondary use of proton pump inhibitors (PPIs) and H2 antagonists, the group of drugs to which Zantac belongs. The study found elevated incidences of esophageal cancer, pharyngeal cancer, liver cancer, and pancreatic cancer, and stomach cancer, among others.

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This assertion was bolstered by an abundance of evidence demonstrating that NDMA exposure is associated with an increased risk of cancer in humans as well as animals.” This research is similar to data from a 2000 study, which investigated the association between prescription ranitidine use and specific cancers. In the 2000 study, researchers found a statistically significant 2.

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Sloan Kettering Study Finds Association Between Ranitidine and Cancer Researchers from the Sloan Kettering Cancer Center conducted the study, ‘Ranitidine use, N-Nitrosodimethylamine (NDMA) production and variations in cancer diagnoses’. The study used similar methods to the 2021 Valisure study above. The Sloan Kettering study analyzed ranitidine NDMA production under various simulated gastric conditions.

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According to the authors, Zantac produces increasing amounts of NDMA over time (up to, and likely beyond four hours) and with increasing sodium nitrite concentrations. The study found positive associations for bladder cancer, breast cancer, prostate cancer, and thyroid cancer. Epidemiological Studies of Zantac and Cancer Very few epidemiological studies of patients taking Zantac have been conducted.

The subjects of the study were asked if they used either Tagamet or Zantac as a treatment. The authors of the study reported that use of either drug was associated with an increased risk of bladder cancer, though the increase fell short of statistical significance. Other Zantac Studies A true Zantac cancer study in humans—where humans are deliberately given Zantac to ingest to observe the results—has not been conducted and never will, as it would be unethical.

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